Endocrine Abstracts

Radioiodine (131-I)- in use for more than 50 years for hyperthyroidism, with or without goitre, and also more recently for non-toxic goitre- has proven effective in the treatment of hyperthyroidism as well as in reducing goitre size. In hyperthyroidism, one or two 131-I doses will cure nearly all patients. Factors such as: sex, age, morphological goitre type, size of goitre, presence of thyroid autoantibodies, and pre- and post-radioiodine antithyroid drug (ATD) therapy influe...

Background: A 52-y-old lady (Mrs M) presented with a 10-day history of progressive generalised weakness, dysarthria and un-coordination. 26 y ago, she had cervical carcinoma, requiring a hysterectomy, oophorectomy and radiotherapy. This led to a vesicovaginal fistula, requiring a cystectomy and ureterosigmoidostomy. She is known to have osteoporosis. Medications: calfovit D3 one/d (started 5 days prior to admission), risedronate, lansoprazole. She had HRT until 50 y. Examinati...

Materials and methods: We investigated 79 normal (1st group) and 99 overweight (2nd group) preschool children. Deficient sport and average physical activity (APA) duration, risen appetite (point-assessment), prolonged television viewing and computer using time in children were considered as risk-factors of juvenile obesity manifestation. Height, weight, waist circumflex (WC) was measured; body mass index (BMI) was calculated. Serum leptin levels were detected by immunoenzyme m...

Introduction: Adipocyte fatty acid binding protein (A-FABP) is a fatty acid chaperone that facilitates the efflux of free fatty acid from cytoplasm into circulation. Previous studies show that A-FABP knockout (KO) mice are more susceptible to diet-induced obesity comparing to wild type (WT) littermates. Here we investigate the underlying mechanism of A-FABP in the regulation of diet-induced obesity.Methods: A-FABP KO mice and their WT littermates were fe...

Introduction: The proto-oncogene KIT (CD117) is widely expressed in neoplastic tissues. Gain-of-function mutations of the KIT gene were found in some types of leukaemia, gastrointestinal stromal tumours, germinal cell tumours and rarely in other malignancies. Studies on the KIT protein and gene in different tumours have been intensified by the availability of imatinibe mesylate, KIT/PDGFRA inhibitor.Methods: We have immunohistochemically investiga...

Background: Signal intensity in T2 weighted (w) MRI in somatotroph pituitary adenomas has been described to correlate with histological granulation pattern. Long-term somato-statin analogue (SSA)-response is associated with both histological subtype and T2wMRI.Objective: To describe secretory baseline characteristics in newly diagnosed acromegalic patients in relation to T2 signal intensity. Moreover, to test whether T2 w images could predict preoperativ...

Aim: To compare gender frequency of leptin receptor gene (LEPR) genotype rates and leptinemia levels in overweight children.Materials and methods: Three hundred children with adiposity were investigated (divided into groups: prepubertal (1st) m/f n=51/50, early pubertal (2nd) n=49/51, late pubertal (3d) n=50/49). 80 girls and 89 boys with obesity and 90 lean girls and 48 lean boys (control) were genotyped in 6 exon of LEPR gene (Q223...

The risk of hypertension is 3-fold increased in women with Turner Syndrome (TS). Coarctation is a known cause of secondary hypertension but for others the aetiology of hypertension is unclear. Studies have demonstrated elevated plasma renin activity (PRA) in girls and young women with TS and hypothesized that the aetiology of hypertension is small vessel renovascular disease. To explore this possibility further blood pressure (BP) and PRA were measured routinely at the Adult T...

Background and aim: In clinical populations, generic quality of life (QoL) questionnaires should be supplemented with disease-specific questionnaires, which may have higher sensitivity and clinical relevance. For the purpose of developing a comprehensive thyroid QoL questionnaire, we have evaluated the relative importance of various QoL aspects to thyroid patients.Methods: A list of problems (issues) related to thyroid diseases, previously identified thr...

Objective: Succinate dehydrogenase B (SDHB) germline mutations are associated with predominantly extra-adrenal paraganglioma (PGLs) and high rates of metastatic disease. Bladder paragangliomas are a rare form of chromaffin cell tumours arising from the bladder wall. The aim of the study is to highlight the preponderance of bladder paragangliomas associated with SDHB gene mutations.Design: Retrospective case series.Patients: Five of...